Issue 4, 2011

A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

Abstract

Nuclear receptors are ligand-regulated transcription factors that control a range of (patho)physiological processes. Lipids are the most common type of nuclear receptor ligands. Here, we utilize a metabolomics approach that detects protein–metabolite interactions to identify endogenous peroxisome proliferator-activated receptor (PPAR) ligands from tissue and cell extracts.

Graphical abstract: A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

Supplementary files

Article information

Article type
Communication
Submitted
11 Dec 2010
Accepted
18 Jan 2011
First published
31 Jan 2011

Mol. BioSyst., 2011,7, 1046-1049

A metabolomics strategy for detecting protein–metabolite interactions to identify natural nuclear receptor ligands

Y. Kim, A. C. Lou and A. Saghatelian, Mol. BioSyst., 2011, 7, 1046 DOI: 10.1039/C0MB00324G

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