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Issue 4, 2011
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A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation

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Abstract

As a versatile pathogen Staphylococcus aureus can cause various disease patterns, which are influenced by strain specific virulence factor repertoires but also by S. aureus physiological adaptation capacity. Here, we present metabolomic descriptions of S. aureus central metabolic pathways and demonstrate the potential for combined metabolomics- and proteomics-based approaches for the basic research of this important pathogen. This study provides a time-resolved picture of more than 500 proteins and 94 metabolites during the transition from exponential growth to glucose starvation. Under glucose excess, cells exhibited higher levels of proteins involved in glycolysis and protein-synthesis, whereas entry into the stationary phase triggered an increase of enzymes of TCC and gluconeogenesis. These alterations in levels of metabolic enzymes were paralleled by more pronounced changes in the concentrations of associated metabolites, in particular, intermediates of the glycolysis and several amino acids.

Graphical abstract: A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation

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Publication details

The article was received on 06 Dec 2010, accepted on 25 Jan 2011 and first published on 16 Feb 2011


Article type: Paper
DOI: 10.1039/C0MB00315H
Citation: Mol. BioSyst., 2011,7, 1241-1253
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    A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation

    M. Liebeke, K. Dörries, D. Zühlke, J. Bernhardt, S. Fuchs, J. Pané-Farré, S. Engelmann, U. Völker, R. Bode, T. Dandekar, U. Lindequist, M. Hecker and M. Lalk, Mol. BioSyst., 2011, 7, 1241
    DOI: 10.1039/C0MB00315H

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