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Issue 23, 2011
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Microfluidic approaches for gene delivery and gene therapy

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Abstract

Recent advances in microfluidics have created new and exciting prospects for gene delivery and therapy. The micro-scaled environment within microfluidic systems enables precise control and optimization of multiple processes and techniques used in gene transfection and the production of gene and drug transporters. Traditional non-viral gene transfection methods, such as electroporation, microinjection and optical gene transfection, are improved from the use of innovative microfluidic systems. Additionally, microfluidic systems have also made the production of many viral and non-viral vectors controlled, automated, and reproducible. In summary, the development and application of microfluidic systems are producing increased efficiency in gene delivery and promise improved gene therapy results.

Graphical abstract: Microfluidic approaches for gene delivery and gene therapy

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Publication details

The article was received on 16 Aug 2011, accepted on 10 Oct 2011 and first published on 26 Oct 2011


Article type: Critical Review
DOI: 10.1039/C1LC20766K
Citation: Lab Chip, 2011,11, 3941-3948
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    Microfluidic approaches for gene delivery and gene therapy

    J. Kim, I. Hwang, D. Britain, T. D. Chung, Y. Sun and D. Kim, Lab Chip, 2011, 11, 3941
    DOI: 10.1039/C1LC20766K

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