Jump to main content
Jump to site search

Issue 24, 2011
Previous Article Next Article

Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

Author affiliations

Abstract

Most laboratory assays take advantage of multi-step protocols to achieve high performance, but conventional paper-based tests (e.g., lateral flow tests) are generally limited to assays that can be carried out in a single fluidic step. We have developed two-dimensional paper networks (2DPNs) that use materials from lateral flow tests but reconfigure them to enable programming of multi-step reagent delivery sequences. The 2DPN uses multiple converging fluid inlets to control the arrival time of each fluid to a detection zone or reaction zone, and it requires a method to disconnect each fluid source in a corresponding timed sequence. Here, we present a method that allows programmed disconnection of fluid sources required for multi-step delivery. A 2DPN with legs of different lengths is inserted into a shared buffer well, and the dropping fluid surface disconnects each leg at in a programmable sequence. This approach could enable multi-step laboratory assays to be converted into simple point-of-care devices that have high performance yet remain easy to use.

Graphical abstract: Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Aug 2011, accepted on 12 Oct 2011 and first published on 28 Oct 2011


Article type: Technical Note
DOI: 10.1039/C1LC20758J
Citation: Lab Chip, 2011,11, 4274-4278
  •   Request permissions

    Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper

    B. R. Lutz, P. Trinh, C. Ball, E. Fu and P. Yager, Lab Chip, 2011, 11, 4274
    DOI: 10.1039/C1LC20758J

Search articles by author

Spotlight

Advertisements