Issue 14, 2011

Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Abstract

Early development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of common formulation processes is a strategy to overcome those limitations. We present a versatile technique for fabricating drug nanoformulations using a microfluidic spray dryer. Nanoparticles are formed by evaporative precipitation of the drug-loaded spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles of 20–60 nm in diameter are prepared with a narrow size distribution. We design the device with a geometry that allows the injection of two separate solvent streams, thus enabling co-spray drying of two substances for the production of drug co-precipitates with tailor-made composition for optimization of therapeutic efficiency.

Graphical abstract: Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

Supplementary files

Article information

Article type
Paper
Submitted
07 Apr 2011
Accepted
27 Apr 2011
First published
26 May 2011

Lab Chip, 2011,11, 2362-2368

Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

J. Thiele, M. Windbergs, A. R. Abate, M. Trebbin, H. C. Shum, S. Förster and D. A. Weitz, Lab Chip, 2011, 11, 2362 DOI: 10.1039/C1LC20298G

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