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Issue 14, 2011
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Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

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Abstract

Early development drug formulation is exacerbated by increasingly poor bioavailability of potential candidates. Prevention of attrition due to formulation problems necessitates physicochemical analysis and formulation studies at a very early stage during development, where the availability of a new substance is limited to small quantities, thus impeding extensive experiments. Miniaturization of common formulation processes is a strategy to overcome those limitations. We present a versatile technique for fabricating drug nanoformulations using a microfluidic spray dryer. Nanoparticles are formed by evaporative precipitation of the drug-loaded spray in air at room temperature. Using danazol as a model drug, amorphous nanoparticles of 20–60 nm in diameter are prepared with a narrow size distribution. We design the device with a geometry that allows the injection of two separate solvent streams, thus enabling co-spray drying of two substances for the production of drug co-precipitates with tailor-made composition for optimization of therapeutic efficiency.

Graphical abstract: Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

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Publication details

The article was received on 07 Apr 2011, accepted on 27 Apr 2011 and first published on 26 May 2011


Article type: Paper
DOI: 10.1039/C1LC20298G
Citation: Lab Chip, 2011,11, 2362-2368
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    Early development drug formulation on a chip: Fabrication of nanoparticles using a microfluidic spray dryer

    J. Thiele, M. Windbergs, A. R. Abate, M. Trebbin, H. C. Shum, S. Förster and D. A. Weitz, Lab Chip, 2011, 11, 2362
    DOI: 10.1039/C1LC20298G

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