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Issue 37, 2011
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DNA nanofabrication by scanning near-field photolithography of oligo(ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation

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Abstract

The use of scanning near-field photolithography (SNP) to fabricate DNA nanostructures is described. Two different strategies were employed to generate nanoscale features in oligo(ethylene glycol) (OEG) terminated alkylthiolate self-assembled monolayers (SAMs) on gold. At long exposure times, complete photooxidation of the SAM molecules enabled their displacement by amino-terminated thiol molecules, which were subsequently used to attach ss-DNA molecules; while short exposure times resulted in partial photochemical conversion of the terminal OEG group of the adsorbate to an aldehyde group facilitating the direct attachment of amino-DNA molecules. Arrays of DNA functionalized metal-nanoparticles were then assembled onto the ss-DNA patches through specific DNA hybridization. This methodology provides a facile approach for the assembly of bio-functionalised nanoparticles onto nanofeatures embedded in an inert background and will prove useful in biosensing applications.

Graphical abstract: DNA nanofabrication by scanning near-field photolithography of oligo(ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation

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Publication details

The article was received on 24 Apr 2011, accepted on 27 May 2011 and first published on 21 Jul 2011


Article type: Paper
DOI: 10.1039/C1JM11803J
Citation: J. Mater. Chem., 2011,21, 14173-14177
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    DNA nanofabrication by scanning near-field photolithography of oligo(ethylene glycol) terminated SAMs: Controlled scan-rate dependent switching between head group oxidation and tail group degradation

    S. Sun, D. G. Thompson, D. Graham and G. J. Leggett, J. Mater. Chem., 2011, 21, 14173
    DOI: 10.1039/C1JM11803J

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