Issue 33, 2011
From the journal:

Journal of Materials Chemistry

Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Eun-Kyung Lim,a   Eunji Jang,a   Bongjune Kim,a   Jihye Choi,a   Kwangyeol Lee,e   Jin-Suck Suh,bcd   Yong-Min Huh*bcd  and  Seungjoo Haam*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, South Korea
E-mail: haam@yonsei.ac.kr
Fax: +82-2-312-6401
Tel: +82-2-2123-3554

b Department of Radiology, College of Medicine, Yonsei University, Seoul, South Korea

c YUHS-KRIBB Medical Convergence Research Institute, Seoul, South Korea

d Severance Biomedical Science Institute(SBSI), Seoul, South Korea

e Department of Chemistry, Korea University, Seoul, South Korea

Abstract

We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophagevia MR imaging.

Graphical abstract: Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

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Article information

DOI
https://doi.org/10.1039/C1JM10764J
Article type
Paper
Submitted
21 Feb 2011
Accepted
06 Jun 2011
First published
21 Jul 2011

J. Mater. Chem., 2011,21, 12473-12478

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Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

E. Lim, E. Jang, B. Kim, J. Choi, K. Lee, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2011, 21, 12473 DOI: 10.1039/C1JM10764J

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