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Issue 6, 2011
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Hydroxy double salts as versatile storage and delivery matrices

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Abstract

The utility of hydroxy double salts (HDSs) for the uptake and delivery of a range of functional anions via ion exchange is demonstrated. Three novel HDS nanocomposites containing medicinal (ibuprofen and diclofenac) and agrochemical (2,4,5-trichlorophenoxyacetic acid) species have been synthesised through ion exchange intercalation. The release of the guest ions from the host has subsequently been explored. A range of models have been applied to the release kinetics. Release of 2,4,5-trichlorophenoxyacetic acid took place over ca. 200 minutes and release of ibuprofen over around 250 minutes. Coating the crystallites of the intercalates with a sodium alginate layer led to release times being extended to approximately 10 hours, which is an appropriate timescale for an effective release system.

Graphical abstract: Hydroxy double salts as versatile storage and delivery matrices

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Publication details

The article was received on 09 Sep 2010, accepted on 01 Nov 2010 and first published on 25 Nov 2010


Article type: Paper
DOI: 10.1039/C0JM03020A
Citation: J. Mater. Chem., 2011,21, 1822-1828
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    Hydroxy double salts as versatile storage and delivery matrices

    R. M. R. Bull, C. Markland, G. R. Williams and D. O'Hare, J. Mater. Chem., 2011, 21, 1822
    DOI: 10.1039/C0JM03020A

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