Jump to main content
Jump to site search

Issue 4, 2011
Previous Article Next Article

Communication theory and multicellular biology

Author affiliations

Abstract

In this Perspective, we propose that communication theory—a field of mathematics concerned with the problems of signal transmission, reception and processing—provides a new quantitative lens for investigating multicellular biology, ancient and modern. What underpins the cohesive organisation and collective behaviour of multicellular ecosystems such as microbial colonies and communities (microbiomes) and multicellular organisms such as plants and animals, whether built of simple tissue layers (sponges) or of complex differentiated cells arranged in tissues and organs (members of the 35 or so phyla of the subkingdom Metazoa)? How do mammalian tissues and organs develop, maintain their architecture, become subverted in disease, and decline with age? How did single-celled organisms coalesce to produce many-celled forms that evolved and diversified into the varied multicellular organisms in existence today? Some answers can be found in the blueprints or recipes encoded in (epi)genomes, yet others lie in the generic physical properties of biological matter such as the ability of cell aggregates to attain a certain complexity in size, shape, and pattern. We suggest that Lasswell's maxim “Who says what to whom in what channel with what effect” provides a foundation for understanding not only the emergence and evolution of multicellularity, but also the assembly and sculpting of multicellular ecosystems and many-celled structures, whether of natural or human-engineered origin. We explore how the abstraction of communication theory as an organising principle for multicellular biology could be realised. We highlight the inherent ability of communication theory to be blind to molecular and/or genetic mechanisms. We describe selected applications that analyse the physics of communication and use energy efficiency as a central tenet. Whilst communication theory has and could contribute to understanding a myriad of problems in biology, investigations of multicellular biology could, in turn, lead to advances in communication theory, especially in the still immature field of network information theory.

Graphical abstract: Communication theory and multicellular biology

Back to tab navigation

Publication details

The article was received on 07 Oct 2010, accepted on 19 Feb 2011 and first published on 22 Mar 2011


Article type: Perspective
DOI: 10.1039/C0IB00117A
Citation: Integr. Biol., 2011,3, 350-367
  •   Request permissions

    Communication theory and multicellular biology

    I. S. Mian and C. Rose, Integr. Biol., 2011, 3, 350
    DOI: 10.1039/C0IB00117A

Search articles by author

Spotlight

Advertisements