In vivo sodium concentration continuously monitored with fluorescent sensors

J. Matthew Dubach; Edward Lim; Ning Zhang; Kevin P. Francis; Heather Clark

doi:10.1039/C0IB00020E

This website uses cookies to give you the best user experience. If you continue without changing your settings we'll assume you are happy to receive all RSC cookies. You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions are also obtainable from the privacy link at the bottom of any RSC page.

skip RSC | ChemSpider | Feedback

Home > Journals > Integrative Biology > In vivo sodium concentr...

For Authors & Referees | For Librarians | For Members

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Integrative Biology

Issue 2, 2011

Interdisciplinary approaches for molecular and cellular life sciences

Impact Factor 4.509 12 Issues per Year

Journal Home

Previous Article | Next Article

Technical Innovation

In vivo sodium concentration continuously monitored with fluorescent sensors

J. Matthew Dubach,^a^b Edward Lim,^c Ning Zhang,^c Kevin P. Francis^c and Heather Clark*^d

Show Affiliations

Hide Affiliations

Corresponding authors

Department of Bioengineering, Northeastern University, 360 Huntington Ave, Boston

The Charles Stark Draper Laboratory, Biomedical Engineering, 555 Technology Square, Cambridge, USA

Caliper Life Science, 2061 Challenger Drive, Alameda, USA

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave, Boston
E-mail: h.clark@neu.edu

Integr. Biol., 2011,3, 142-148

DOI: 10.1039/C0IB00020E
Received 31 Mar 2010, Accepted 17 Sep 2010
First published online 19 Nov 2010

Please wait while Download options loads

Download Citation

Request Permissions

Abstract
Cited by
Compounds
Related Content

Sodium balance is vital to maintaining normal physiological function. Imbalances can occur in a variety of diseases, during certain surgical operations or during rigorous exercise. There is currently no method to continuously monitor sodium concentration in patients who may be susceptible to hyponatremia. Our approach was to design sodium specific fluorescent sensors capable of measuring physiological fluctuations in sodium concentration. The sensors are submicron plasticized polymer particles containing sodium recognition components that are coated with biocompatible poly(ethylene) glycol. Here, the sensors were brought up in saline and placed in the subcutaneous area of the skin of mice by simple injection. The fluorescence was monitored in real time using a whole animal imager to track changes in sodium concentrations. This technology could be used to monitor certain disease states or warn against dangerously low levels of sodium during exercise.

This may take some time to load.

Integrative Biology - Information Point

About this Journal

People and Contacts

Submit to this Journal

Editorial Board

Authors and Referees

Subscription Information

Follow Journal | |

Search Articles By

J. Matthew Dubach
Edward Lim
Ning Zhang
Kevin P. Francis
Heather Clark

Related Patents

View patents from SureChem

Terms & Conditions|Privacy and Cookies |Accessibility|ACAP Enabled

Integrative Biology

In vivo sodium concentration continuously monitored with fluorescent sensors

Log in (Free Access)

Log in (Subscriber Access)

Search Articles By

Related Patents

Integrative Biology

In vivo sodium concentration continuously monitored with fluorescent sensors

This text is added as a work around for heading error in Accessibility testing

Log in (Free Access)

Log in (Subscriber Access)

Search Articles By

Related Patents