Cu2O acting as a robust catalyst in CuAAC reactions: water is the required medium

Kai Wang; Xihe Bi; Shuangxi Xing; Peiqiu Liao; Zhongxue Fang; Xianyu Meng; Qian Zhang; Qun Liu; Yu Ji

doi:10.1039/C0GC00848F

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Cu₂O acting as a robust catalyst in CuAAC reactions: water is the required medium†

Kai Wang,^a Xihe Bi,*^a Shuangxi Xing,^a Peiqiu Liao,^a Zhongxue Fang,^a Xianyu Meng,^a Qian Zhang,*^a Qun Liu^a and Yu Ji^a

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* Corresponding authors

^a Department of Chemistry, Northeast Normal University, Changchun, China
E-mail: bixh507@nenu.edu.cn, zhangq651@nenu.edu.cn

Abstract

Cu₂O as the catalyst in water was found to be quite robust for the azide-alkyne cycloaddition (AAC) reaction, which was verified by a wide variety of applicable azides and alkynes. Water was proved to play an essential role because of a significant rate acceleration compared with reactions using organic solvents and conducted under neat conditions. The high catalytic performance of Cu₂O/H₂O system was further argued by decreasing the catalyst loading to ppm levels.

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Article information

DOI: https://doi.org/10.1039/C0GC00848F
Article type: Communication
Submitted: 25 Nov 2010
Accepted: 23 Dec 2010
First published: 25 Jan 2011

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Green Chem., 2011,13, 562-565

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Cu₂O acting as a robust catalyst in CuAAC reactions: water is the required medium

K. Wang, X. Bi, S. Xing, P. Liao, Z. Fang, X. Meng, Q. Zhang, Q. Liu and Y. Ji, Green Chem., 2011, 13, 562 DOI: 10.1039/C0GC00848F

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