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Issue 4, 2011
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Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

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Abstract

Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes is accomplished by a three-step synthesis including multicomponent reaction (MCR) to form tetrahydroquinoline, followed by cycloaddition with coumarin to form oxazabicycles, and then a Suzuki coupling to introduce the biaryl group. Microwave irradiation and fluorous solid-phase extraction (F-SPE) are employed to speed up reactions and simplify product purification.

Graphical abstract: Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

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Publication details

The article was received on 24 Oct 2010, accepted on 16 Feb 2011 and first published on 08 Mar 2011


Article type: Communication
DOI: 10.1039/C0GC00725K
Citation: Green Chem., 2011,13, 847-849
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    Fluorous benzaldehyde-based synthesis of biaryl-substituted oxazabicyclo[3.3.1]nonanes

    S. Ding, M. Le-Nguyen, T. Xu and W. Zhang, Green Chem., 2011, 13, 847
    DOI: 10.1039/C0GC00725K

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