Issue 18, 2011
From the journal:

Dalton Transactions

The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers†

Yong Zhang,ab   Li-Yuan Chen,a   Wen-Xing Yin,a   Jun Yin,a   Shi-Bing Zhanga  and  Chang-Lin Liu*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, School of Chemistry, Central China Normal University, Wuhan, P. R. China
E-mail: liuchl@mail.ccnu.edu.cn

b School of Chemical and Materials Engineering, Huangshi Institute of Technology, Huangshi, P. R. China

Abstract

The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu2+ and Zn2+ and can target metal–Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.

Graphical abstract: The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

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Article information

DOI
https://doi.org/10.1039/C1DT00020A
Article type
Communication
Submitted
06 Jan 2011
Accepted
08 Mar 2011
First published
24 Mar 2011

Dalton Trans., 2011,40, 4830-4833

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The chelation targeting metal–Aβ40 aggregates may lead to formation of Aβ40 oligomers

Y. Zhang, L. Chen, W. Yin, J. Yin, S. Zhang and C. Liu, Dalton Trans., 2011, 40, 4830 DOI: 10.1039/C1DT00020A

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