Issue 23, 2011

Multimodality and nanoparticles in medical imaging

Abstract

A number of medical imaging techniques are used heavily in the provision of spatially resolved information on disease and physiological status and accordingly play a critical role in clinical diagnostics and subsequent treatment. Though, for most imaging modes, contrast is potentially enhanced through the use of contrast agents or improved hardware or imaging protocols, no single methodology provides, in isolation, a detailed mapping of anatomy, disease markers or physiological status. In recent years, the concept of complementing the strengths of one imaging modality with those of another has come to the fore and been further bolstered by the development of fused instruments such as PET/CT and PET/MRI stations. Coupled with the continual development in imaging hardware has been a surge in reports of contrast agents bearing multiple functionality, potentially providing not only a powerful and highly sensitised means of co-localising physiological/disease status and anatomy, but also the tracking and delineation of multiple markers and indeed subsequent or simultaneous highly localized therapy (“theragnostics”).

Graphical abstract: Multimodality and nanoparticles in medical imaging

Article information

Article type
Perspective
Submitted
29 Nov 2010
Accepted
02 Feb 2011
First published
14 Mar 2011

Dalton Trans., 2011,40, 6087-6103

Multimodality and nanoparticles in medical imaging

W. Huang and J. J. Davis, Dalton Trans., 2011, 40, 6087 DOI: 10.1039/C0DT01656J

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