Issue 7, 2011
From the journal:

Catalysis Science & Technology

Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkylGrignard reagents or arylboronic acids†

Manabu Hatano,a   Riku Gouzu,b   Tomokazu Mizuno,a   Hitoshi Abe,b   Toshihide Yamadab  and  Kazuaki Ishihara*ac  

* Corresponding authors

a Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan
E-mail: ishihara@cc.nagoya-u.ac.jp
Fax: +81-52-789-3331
Tel: +81-52-789-3222

b Sekisui Medical Co., Ltd, 4-115, Matsuo, Hachimantai, Iwate, Japan

c Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa, Nagoya, Japan

Abstract

A highly practical, catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents, which were prepared in situ from commercially available Grignard reagents or arylboronic acids, was developed. A chiral phosphoramide ligand was essential for promoting the addition reactions in high yields with high enantioselectivities.

Graphical abstract: Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

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Article information

DOI
https://doi.org/10.1039/C1CY00108F
Article type
Paper
Submitted
28 Mar 2011
Accepted
02 Jun 2011
First published
01 Jul 2011

Catal. Sci. Technol., 2011,1, 1149-1158

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Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

M. Hatano, R. Gouzu, T. Mizuno, H. Abe, T. Yamada and K. Ishihara, Catal. Sci. Technol., 2011, 1, 1149 DOI: 10.1039/C1CY00108F

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