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Issue 10, 2011
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35 years of palladium-catalyzed cross-coupling with Grignard reagents: how far have we come?

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Abstract

This tutorial review is intended to provide the reader with a timely review of major developments and the current state-of-the-art of palladium-catalyzed cross-coupling reactions with Grignard reagents. Organomagnesium reagents, the most reactive and most easily accessible nucleophiles for carbon–carbon bond forming cross-coupling reactions, were the first nucleophiles ever employed in cross-coupling reactions, but have only recently been re-discovered for highly efficient and (stereo)selective coupling reactions. This is mostly a consequence of improved catalyst systems with bulky phosphine, phosphonate or carbene ligands and new metal–halogen exchange procedures for the generation of functionalized Grignard reagents.

Graphical abstract: 35 years of palladium-catalyzed cross-coupling with Grignard reagents: how far have we come?

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Publication details

The article was received on 24 May 2011 and first published on 02 Aug 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15137A
Citation: Chem. Soc. Rev., 2011,40, 4948-4962
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    35 years of palladium-catalyzed cross-coupling with Grignard reagents: how far have we come?

    C. E. I. Knappke and A. Jacobi von Wangelin, Chem. Soc. Rev., 2011, 40, 4948
    DOI: 10.1039/C1CS15137A

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