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Issue 19, 2011
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Functional liposomes and supported lipid bilayers: towards the complexity of biological archetypes

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Abstract

This perspective paper provides some illustrative examples on the interplay between information gathered on planar supported lipid bilayers (SLB) and unilamellar lipid vesicles (ULV) to get an integrated description of phenomena occurring at the nanoscale that involve locally bilayered structures. Similarities and differences are underlined and critically compared in terms of biomimetic fidelity and instrumental accessibility to structural and dynamical parameters, focusing on some recent reports that either explicitly address this comparison or introducing some studies that separately investigate the same process in SLB and lipid vesicles. Despite the structural similarity on the nanoscale, the different topology implies radically different characterization techniques that have evolved in sectorial and separated approaches. The quest for increasing levels of compositional complexity for bilayered systems should not result in a loss of structural and dynamical control: this is the central challenge of future research in this area, where the integrated approach highlighted in this contribution would enable improved levels of understanding.

Graphical abstract: Functional liposomes and supported lipid bilayers: towards the complexity of biological archetypes

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Publication details

The article was received on 04 Nov 2010, accepted on 28 Feb 2011 and first published on 01 Apr 2011


Article type: Perspective
DOI: 10.1039/C0CP02400G
Citation: Phys. Chem. Chem. Phys., 2011,13, 8769-8782
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    Functional liposomes and supported lipid bilayers: towards the complexity of biological archetypes

    D. Berti, G. Caminati and P. Baglioni, Phys. Chem. Chem. Phys., 2011, 13, 8769
    DOI: 10.1039/C0CP02400G

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