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Issue 43, 2011
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Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes

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Abstract

We have developed hybrid P450 BM3 enzymes consisting of a Ru(II)-diimine photosensitizer covalently attached to non-native single cysteine residues of P450 BM3 heme domain mutants. These enzymes are capable, upon light activation, of selectively hydroxylating lauric acid with 40 times higher total turnover numbers compared to the peroxide shunt.

Graphical abstract: Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes

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Publication details

The article was received on 17 Aug 2011, accepted on 15 Sep 2011 and first published on 05 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15124J
Citation: Chem. Commun., 2011,47, 11936-11938
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    Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes

    N. Tran, N. Huynh, T. Bui, Y. Nguyen, P. Huynh, M. E. Cooper and L. E. Cheruzel, Chem. Commun., 2011, 47, 11936
    DOI: 10.1039/C1CC15124J

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