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Issue 42, 2011
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An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines

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Abstract

An aerobic oxidative cross-dehydrogenative coupling reaction between sp3 C–H and sp2 C–H bonds is developed by employing a vanadium catalyst (10 mol%) in an aqueous medium using molecular oxygen as the oxidant. This environmentally benign strategy exhibits larger substrate scope and shows high regioselectivity.

Graphical abstract: An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines

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Publication details

The article was received on 14 Aug 2011, accepted on 12 Sep 2011 and first published on 28 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC15050B
Citation: Chem. Commun., 2011,47, 11787-11789
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    An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines

    K. Alagiri, G. S. R. Kumara and K. R. Prabhu, Chem. Commun., 2011, 47, 11787
    DOI: 10.1039/C1CC15050B

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