Issue 41, 2011

Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules

Abstract

A convenient synthesis of azidomethyl-ruthenocene and its use in the covalent labelling of amino acids, peptides and a peptide nucleic acid (PNA) monomer derivative by Cu(I) catalyzed azide–alkyne coupling (Cu-AAC, “click chemistry”) are described.

Graphical abstract: Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules

Supplementary files

Article information

Article type
Communication
Submitted
25 Jul 2011
Accepted
12 Sep 2011
First published
21 Sep 2011

Chem. Commun., 2011,47, 11444-11446

Azidomethyl-ruthenocene: facile synthesis of a useful metallocene derivative and its application in the ‘click’ labelling of biomolecules

M. Patra and N. Metzler-Nolte, Chem. Commun., 2011, 47, 11444 DOI: 10.1039/C1CC14537A

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