Issue 35, 2011

Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Abstract

The enantiospecific and diastereocontrolled total synthesis of alkaloid (−)-217A is described that employs a stepwise [3+3] annelation strategy and a piperidine 2,3-cyclopropanation–ring opening reaction as the key steps.

Graphical abstract: Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

Supplementary files

Article information

Article type
Communication
Submitted
24 May 2011
Accepted
20 Jul 2011
First published
05 Aug 2011

Chem. Commun., 2011,47, 9804-9806

Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (−)-217A

N. C. Mancey, N. Sandon, A. Auvinet, R. J. Butlin, W. Czechtizky and J. P. A. Harrity, Chem. Commun., 2011, 47, 9804 DOI: 10.1039/C1CC13048J

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