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Issue 29, 2011
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A small molecule that induces assembly of a four way DNA junction at low temperature

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Abstract

Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

Graphical abstract: A small molecule that induces assembly of a four way DNA junction at low temperature

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Publication details

The article was received on 18 May 2011, accepted on 09 Jun 2011 and first published on 24 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC12922H
Citation: Chem. Commun., 2011,47, 8262-8264
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    A small molecule that induces assembly of a four way DNA junction at low temperature

    L. A. Howell, Z. A. E. Waller, R. Bowater, M. O'Connell and M. Searcey, Chem. Commun., 2011, 47, 8262
    DOI: 10.1039/C1CC12922H

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