Issue 30, 2011
From the journal:

Chemical Communications

Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes†

Subhadeep Roy,a   Kimberly J. Zanotti,a   Connor T. Murphy,a   Farial A. Tanious,b   W. David Wilson,b   Danith H. Lya  and  Bruce A. Armitage*a  

* Corresponding authors

a Department of Chemistry and Center for Nucleic Acids Science and Technology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, USA
E-mail: army@cmu.edu
Fax: 412-268-1061
Tel: 412-268-4196

b Department of Chemistry, Georgia State University, Atlanta

Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA–DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.

Graphical abstract: Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

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Article information

DOI
https://doi.org/10.1039/C1CC12805A
Article type
Communication
Submitted
12 May 2011
Accepted
16 Jun 2011
First published
30 Jun 2011

Chem. Commun., 2011,47, 8524-8526

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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes

S. Roy, K. J. Zanotti, C. T. Murphy, F. A. Tanious, W. D. Wilson, D. H. Ly and B. A. Armitage, Chem. Commun., 2011, 47, 8524 DOI: 10.1039/C1CC12805A

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