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Issue 37, 2011
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Quantitative genotyping of single nucleotide polymorphism by single-molecule multi-color fluorescence resonance energy transfer

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Abstract

We developed a new single nucleotide polymorphism (SNP) genotyping method based on single-molecule multi-color fluorescence resonance energy transfer (FRET). We demonstrated that this new method uses less than 1 fmol of sample and is also highly quantitative with a detection level of 1% or lower in the minor allele fraction.

Graphical abstract: Quantitative genotyping of single nucleotide polymorphism by single-molecule multi-color fluorescence resonance energy transfer

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Publication details

The article was received on 10 May 2011, accepted on 27 Jul 2011 and first published on 17 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC12737C
Citation: Chem. Commun., 2011,47, 10362-10364
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    Quantitative genotyping of single nucleotide polymorphism by single-molecule multi-color fluorescence resonance energy transfer

    H. R. Koh, K. Y. Han, J. Jung and S. K. Kim, Chem. Commun., 2011, 47, 10362
    DOI: 10.1039/C1CC12737C

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