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Issue 33, 2011
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Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

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Abstract

An atom-economical purification protocol, using solution phase processing viaring-opening metathesis polymerization (ROMP) has been developed for the synthesis of tricyclic sultams. This chromatography-free method allows for convenient isolation of reductive-Heck products and reclamation of excess starting material via sequestration involving metathesis catalysts and a catalyst-armed Si-surface.

Graphical abstract: Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

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Publication details

The article was received on 28 Apr 2011, accepted on 25 May 2011 and first published on 05 Jul 2011


Article type: Communication
DOI: 10.1039/C1CC12503F
Citation: Chem. Commun., 2011,47, 9528-9530
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    Synthesis of epoxybenzo[d]isothiazole 1,1-dioxides via a reductive-Heck, metathesis-sequestration protocol

    N. Asad, P. R. Hanson, T. R. Long, D. K. Rayabarapu and A. Rolfe, Chem. Commun., 2011, 47, 9528
    DOI: 10.1039/C1CC12503F

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