Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4

G. Rajeshwar Reddy; T. Ram Reddy; Suju C. Joseph; K. Sateesh Reddy; L. Srinivasula Reddy; P. Mahesh Kumar; G. Rama Krishna; C. Malla Reddy; D. Rambabu; Ravikumar Kapavarapu; Chandana Lakshmi; Teja Meda; K. Krishna Priya; Kishore V. L. Parsa; Manojit Pal

doi:10.1039/C1CC12321A

Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4†

G. Rajeshwar Reddy,^ab T. Ram Reddy,^a Suju C. Joseph,^a K. Sateesh Reddy,^a L. Srinivasula Reddy,^a P. Mahesh Kumar,^a G. Rama Krishna,^c C. Malla Reddy,^c D. Rambabu,^d Ravikumar Kapavarapu,^d Chandana Lakshmi,^d Teja Meda,^d K. Krishna Priya,^d Kishore V. L. Parsa^d and Manojit Pal*^d

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* Corresponding authors

^a Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500 049, India

^b Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, Andhra Pradesh, India

^c Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal, India

^d Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com

Abstract

A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.

Chemical Communications

Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4†

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Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4

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