Issue 28, 2011
From the journal:

Chemical Communications

Straightforward four-component access to spiroindolines†

Laurent El Kaïm,*a   Laurence Grimaud,*a   Xavier-Frédéric Le Goff,b   Martha Menes-Arzatec  and  Luis D. Miranda*d  

* Corresponding authors

a UMR 7652 (Ecole Polytechnique/ENSTA/CNRS), Laboratoire Chimie et Procédés, Ecole Nationale Supérieure des Techniques Avancées, 32 Bd Victor, 75015 Paris, France
E-mail: laurent.elkaim@ensta.fr, laurence.grimaud@ensta.fr
Fax: +33 145528322
Tel: +33 145525537

b Laboratoire Hétéroéléments et Coordination, Ecole Polytechnique, CNRS, route de Saclay, F-91128 Palaiseau Cedex, France

c Facultad Medicina, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Mexico D. F. 04510, Mexico

d Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Coyoacan, Mexico D. F. 04510, Mexico
E-mail: lmiranda@servidor.unam.mx
Fax: +52 5556162217
Tel: +52 5556224440

Abstract

Spiroindolines could be synthesized via a very convenient one-pot procedure combining a Ugi coupling and a new copper-catalyzed oxidative process at a peptidyl position. Due to the nature of the first step, this method offers a straightforward access to complex alkaloids with four points of molecular diversity.

Graphical abstract: Straightforward four-component access to spiroindolines

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Article information

DOI
https://doi.org/10.1039/C1CC12236C
Article type
Communication
Submitted
18 Apr 2011
Accepted
24 May 2011
First published
14 Jun 2011

Chem. Commun., 2011,47, 8145-8147

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Straightforward four-component access to spiroindolines

L. El Kaïm, L. Grimaud, X. Le Goff, M. Menes-Arzate and L. D. Miranda, Chem. Commun., 2011, 47, 8145 DOI: 10.1039/C1CC12236C

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