Issue 26, 2011
From the journal:

Chemical Communications

Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe†

Krishna Kanta Ghosh,a   Hyung-Ho Ha,b   Nam-Young Kang,c   Yogeswari Chandranc  and  Young-Tae Chang*ac  

* Corresponding authors

a Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543 Singapore, Singapore
E-mail: chmcyt@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-7794

b College of Pharmacy, Sunchon National University, 540-742, South Korea

c Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, #02-02 Helios Building, 138667 Singapore, Singapore

Abstract

We report the first solid phase synthesis of a xanthone library CX and its application to embryonic stem cell probe development. The CX library was further derivatised with an activated ester resin to provide an acetylated CX (CXAC) library. Screening of these libraries led to the discovery of a novel fluorescent mESC probe, CDb8.

Graphical abstract: Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

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Article information

DOI
https://doi.org/10.1039/C1CC11962A
Article type
Communication
Submitted
07 Apr 2011
Accepted
17 May 2011
First published
01 Jun 2011

Chem. Commun., 2011,47, 7488-7490

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Solid phase combinatorial synthesis of a xanthone library using click chemistry and its application to an embryonic stem cell probe

K. K. Ghosh, H. Ha, N. Kang, Y. Chandran and Y. Chang, Chem. Commun., 2011, 47, 7488 DOI: 10.1039/C1CC11962A

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