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Issue 24, 2011
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Palladium-catalyzed synthesis of indolesviaammonia cross-coupling–alkyne cyclization

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Abstract

The synthesis of indolesvia the metal-catalyzed cross-coupling of ammonia is reported for the first time; the developed protocol also allows for the unprecedented use of methylamine or hydrazine as coupling partners. These Pd/Josiphos-catalyzed reactions proceed under relatively mild conditions for a range of 2-alkynylbromoarenes.

Graphical abstract: Palladium-catalyzed synthesis of indolesviaammonia cross-coupling–alkyne cyclization

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Publication details

The article was received on 01 Apr 2011, accepted on 19 Apr 2011 and first published on 18 May 2011


Article type: Communication
DOI: 10.1039/C1CC11874A
Citation: Chem. Commun., 2011,47, 6936-6938
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    Palladium-catalyzed synthesis of indolesviaammonia cross-coupling–alkyne cyclization

    P. G. Alsabeh, R. J. Lundgren, L. E. Longobardi and M. Stradiotto, Chem. Commun., 2011, 47, 6936
    DOI: 10.1039/C1CC11874A

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