Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction

Montserrat Shelbourne; Xiong Chen; Tom Brown; Afaf H. El-Sagheer

doi:10.1039/C1CC10743G

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Chemical Communications

Issue 22, 2011

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Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction

Montserrat Shelbourne , Xiong Chen , Tom Brown and Afaf H. El-Sagheer

Chem. Commun., 2011,47, 6257-6259

DOI: 10.1039/C1CC10743G
Received 08 Feb 2011, Accepted 12 Apr 2011
First published on the web 06 May 2011

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Templated DNA strand ligation by the ring-strain promoted alkyne–azide [3+2] cycloaddition reaction is very fast; with dibenzocyclooctyne, the reaction is essentially complete in 1 min. It is inhibited by the presence of a single mismatched base pair suggesting applications in genetic analysis.