Issue 17, 2011
From the journal:

Chemical Communications

Mechanism of glutaredoxin—ISU [2Fe–2S] cluster exchange†

Wenbin Qia  and  J. A. Cowan*ab  

* Corresponding authors

a Ohio State Biochemistry Program, The Ohio State University, 100 West 18thAvenue, Columbus, USA
E-mail: Cowan@chemistry.ohio-state.edu

b Department of Chemistry, The Ohio State University, 100 West 18thAvenue, Columbus, USA

Abstract

Exchange of [2Fe–2S] centers between Grx2 and the cluster scaffold protein ISU, and characterization of two mutually exclusive Grx2 binding sites on ISU by isothermal titration calorimetry supports a direct link for Grx and glutathione involvement in ISU promoted Fe–S cluster biosynthesis.

Graphical abstract: Mechanism of glutaredoxin—ISU [2Fe–2S] cluster exchange

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Article information

DOI
https://doi.org/10.1039/C0CC05079B
Article type
Communication
Submitted
21 Nov 2010
Accepted
01 Mar 2011
First published
25 Mar 2011

Chem. Commun., 2011,47, 4989-4991

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Mechanism of glutaredoxin—ISU [2Fe–2S] cluster exchange

W. Qi and J. A. Cowan, Chem. Commun., 2011, 47, 4989 DOI: 10.1039/C0CC05079B

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