Bacteria-based AND logic gate: a decision-making and self-powered biosensor

Zhongjian Li; Miriam A. Rosenbaum; Arvind Venkataraman; Tsz Kin Tam; Evgeny Katz; Largus T. Angenent

doi:10.1039/C0CC05037G

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Chemical Communications

Issue 11, 2011

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Bacteria-based AND logic gate: a decision-making and self-powered biosensor

Zhongjian Li , Miriam A. Rosenbaum , Arvind Venkataraman , Tsz Kin Tam , Evgeny Katz and Largus T. Angenent

Chem. Commun., 2011,47, 3060-3062

DOI: 10.1039/C0CC05037G
Received 18 Nov 2010, Accepted 09 Dec 2010
First published on the web 04 Jan 2011

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We developed a bacteria-based AND logic gate using a Pseudomonas aeruginosa lasI/rhlI double mutant with two quorum-sensing signaling molecules as the input signals. We showed a distinct electrical output signal, despite the complexity and continuous regulation of metabolic reactions of living cells.