Jump to main content
Jump to site search

Issue 5, 2011
Previous Article Next Article

Catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines by phase-transfer catalyzed alkylations

Author affiliations

Abstract

Efficient catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines has been achieved via asymmetric alkylation of 1-cyanotetrahydro-β-carbolines using a binaphthyl-modified N-spiro-type chiral phase-transfer catalyst. This is a valuable example of hitherto difficult highly enantioselective alkylations at α-carbon of the cyano group under phase-transfer conditions.

Graphical abstract: Catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines by phase-transfer catalyzed alkylations

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Oct 2010, accepted on 01 Nov 2010 and first published on 19 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04447D
Citation: Chem. Commun., 2011,47, 1515-1517
  •   Request permissions

    Catalytic asymmetric synthesis of 1,1-disubstituted tetrahydro-β-carbolines by phase-transfer catalyzed alkylations

    S. Shirakawa, K. Liu, H. Ito and K. Maruoka, Chem. Commun., 2011, 47, 1515
    DOI: 10.1039/C0CC04447D

Search articles by author

Spotlight

Advertisements