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Issue 9, 2011
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Cytochromes P450 as useful biocatalysts: addressing the limitations

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Abstract

Cytochrome P450 monooxygenases (P450s or CYPs) are a unique family of enzymes which are capable of catalysing the regio- and stereospecific oxidation of non-functionalised hydrocarbons. Despite the enormous synthetic potential of P450s, these enzymes have yet to be extensively employed for research purposes or in industry. Lack of stability, low activity, narrow substrate specificity, expensive cofactor requirements, limited solvent tolerance and electron supply are some of the main reasons why the academic and industrial implementation of these important biocatalysts remains a challenge. Considering the significance of P450s, many research groups have focused on improving their properties in an effort to make more robust catalysts with broad synthetic applications. This article focuses on some of the factors that have limited the exploitation of P450s and explores some of the significant steps that have been taken towards addressing these limitations.

Graphical abstract: Cytochromes P450 as useful biocatalysts: addressing the limitations

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Publication details

The article was received on 10 Aug 2010, accepted on 07 Dec 2010 and first published on 24 Jan 2011


Article type: Feature Article
DOI: 10.1039/C0CC03165H
Citation: Chem. Commun., 2011,47, 2490-2501
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    Cytochromes P450 as useful biocatalysts: addressing the limitations

    E. O'Reilly, V. Köhler, S. L. Flitsch and N. J. Turner, Chem. Commun., 2011, 47, 2490
    DOI: 10.1039/C0CC03165H

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