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Issue 11, 2011
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Subcellular features revealed on unfixed rat brain sections by phase imaging

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Abstract

For sectioned biologic tissues, atomic force microscopy (AFM) topographic images alone hardly provide adequate information leading to revealing biological structures. We demonstrate that phase imaging in amplitude-modulation AFM is a powerful tool in mapping structures present on the surface of unfixed rat brains sections. The contrast in phase images is originated from the difference in mechanical properties between biological structures. Visualization of the native state of biological structures by way of their mechanical properties provides a complementary technique to more traditional imaging techniques such as optical and electron microscopy.

Graphical abstract: Subcellular features revealed on unfixed rat brain sections by phase imaging

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Publication details

The article was received on 16 Feb 2011, accepted on 23 Mar 2011 and first published on 20 Apr 2011


Article type: Paper
DOI: 10.1039/C1AN15125H
Citation: Analyst, 2011,136, 2270-2276
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    Subcellular features revealed on unfixed rat brain sections by phase imaging

    H.-Y. Nie, A. R. Taylor, W. M. Lau and D. F. MacFabe, Analyst, 2011, 136, 2270
    DOI: 10.1039/C1AN15125H

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