Issue 15, 2011

Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries

Abstract

Throughout history, poor quality medicines have been a persistent problem, with periodical crises in the supply of antimicrobials, such as fake cinchona bark in the 1600s and fake quinine in the 1800s. Regrettably, this problem seems to have grown in the last decade, especially afflicting unsuspecting patients and those seeking medicines via on-line pharmacies. Here we discuss some of the challenges related to the fight against poor quality drugs, and counterfeits in particular, with an emphasis on the analytical tools available, their relative performance, and the necessary workflows needed for distinguishing between genuine, substandard, degraded and counterfeit medicines.

Graphical abstract: Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries

Article information

Article type
Paper
Submitted
11 Aug 2010
Accepted
22 Oct 2010
First published
25 Nov 2010

Analyst, 2011,136, 3073-3082

Poor quality drugs: grand challenges in high throughput detection, countrywide sampling, and forensics in developing countries

F. M. Fernandez, D. Hostetler, K. Powell, H. Kaur, M. D. Green, D. C. Mildenhall and P. N. Newton, Analyst, 2011, 136, 3073 DOI: 10.1039/C0AN00627K

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