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Issue 17, 2011
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The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides

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Abstract

Dehydrotryptophan and its derivatives are non-proteinogenic amino acids commonly found in peptide-based natural products produced by microorganisms, marine organisms and plants. These non-proteinogenic amino acids are found in secondary metabolites and are formed by post translational modification processes. Although comprehensive reviews on the synthesis of dehydroamino acids are available, this perspective focuses solely on methods to synthesise the dehydrotryptophan-containing segment of naturally occurring peptides, amino acids and their derivatives.

Graphical abstract: The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides

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Publication details

The article was received on 18 May 2011, accepted on 24 Jun 2011 and first published on 08 Jul 2011


Article type: Perspective
DOI: 10.1039/C1OB05777D
Citation: Org. Biomol. Chem., 2011,9, 5897-5907
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    The synthesis of dehydrotryptophan and dehydrotryptophan-containing peptides

    H. Kaur, A. M. Heapy and M. A. Brimble, Org. Biomol. Chem., 2011, 9, 5897
    DOI: 10.1039/C1OB05777D

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