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Issue 21, 2011
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Large-scale plasmonic microarrays for label-free high-throughput screening

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Abstract

Microarrays allowing simultaneous analysis of thousands of parameters can significantly accelerate screening of large libraries of pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, label-free, and high-content microarrays are needed. In this work, using large-area plasmonic nanohole arrays, we demonstrate for the first time a large-scale label-free microarray technology with over one million sensors on a single microscope slide. A dual-color filter imaging method is introduced to dramatically increase the accuracy, reliability, and signal-to-noise ratio of the sensors in a highly multiplexed manner. We used our technology to quantitatively measure protein-protein interactions. Our platform, which is highly compatible with the current microarray scanning systems can enable a powerful screening technology and facilitate diagnosis and treatment of diseases.

Graphical abstract: Large-scale plasmonic microarrays for label-free high-throughput screening

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Publication details

The article was received on 01 Jun 2011, accepted on 09 Aug 2011 and first published on 07 Sep 2011


Article type: Paper
DOI: 10.1039/C1LC20475K
Citation: Lab Chip, 2011,11, 3596-3602
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    Large-scale plasmonic microarrays for label-free high-throughput screening

    T. Chang, M. Huang, A. A. Yanik, H. Tsai, P. Shi, S. Aksu, M. F. Yanik and H. Altug, Lab Chip, 2011, 11, 3596
    DOI: 10.1039/C1LC20475K

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