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Issue 13, 2011
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“Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

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Abstract

We have developed a method to monitor the activities of human taste receptor protein in lipid membrane using carbon nanotube transistors, enabling a “bioelectronic super-taster (BST)”, a taste sensor with human-tongue-like selectivity. In this work, human bitter taste receptor protein expressed in E. coli was immobilized on a single-walled carbon nanotube field effect transistor (swCNT-FET) with the lipid membrane. Then, the protein binding activity was monitored using the underlying swCNT-FET, leading to the operation as a BST device. The fabricated BST device could detect bitter tastants at 100 fM concentrations and distinguish between bitter and non-bitter tastants with similar chemical structures just like a human tongue. Furthermore, this strategy was utilized to differentiate the responses of taster or non-taster types of the bitter taste receptor proteins.

Graphical abstract: “Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

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Publication details

The article was received on 01 Dec 2010, accepted on 24 Mar 2011 and first published on 05 May 2011


Article type: Paper
DOI: 10.1039/C0LC00648C
Citation: Lab Chip, 2011,11, 2262-2267
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    “Bioelectronic super-taster” device based on taste receptor-carbon nanotube hybrid structures

    T. H. Kim, H. S. Song, H. J. Jin, S. H. Lee, S. Namgung, U. Kim, T. H. Park and S. Hong, Lab Chip, 2011, 11, 2262
    DOI: 10.1039/C0LC00648C

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