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Issue 23, 2011
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Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

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Abstract

We report a doxorubicin loaded chitosan biopolymer–ferromagnetic disks hybrid system capable of on-demand magnetomechanically induced release of drug molecules. Gold covered ferromagnetic disks were encapsulated into the polymer scaffold through the assembly of the thiolated chitosan on the disk's gold surface followed by entrapping of the doxorubicin drug within a cross-linked polymer matrix. We demonstrate that the release process can be effectively tuned and controlled by varying the magnetic field characteristics: orientation, amplitude, frequency and duration.

Graphical abstract: Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

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Publication details

The article was received on 18 Jan 2011, accepted on 23 Feb 2011 and first published on 24 Mar 2011


Article type: Paper
DOI: 10.1039/C1JM10272A
Citation: J. Mater. Chem., 2011,21, 8422-8426
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    Mechanoresponsive system based on sub-micron chitosan-functionalized ferromagnetic disks

    D. Kim, P. Karavayev, E. A. Rozhkova, J. Pearson, V. Yefremenko, S. D. Bader and V. Novosad, J. Mater. Chem., 2011, 21, 8422
    DOI: 10.1039/C1JM10272A

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