Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

Shaun D. Gittard; Philip R. Miller; Ryan D. Boehm; Aleksandr Ovsianikov; Boris N. Chichkov; Jeremy Heiser; John Gordon; Nancy A. Monteiro-Riviere; Roger J. Narayan

doi:10.1039/C005374K

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Faraday Discussions

Issue 0, 2011

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Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles

Shaun D. Gittard , Philip R. Miller , Ryan D. Boehm , Aleksandr Ovsianikov , Boris N. Chichkov , Jeremy Heiser , John Gordon , Nancy A. Monteiro-Riviere and Roger J. Narayan

Faraday Discuss., 2011,149, 171-185

DOI: 10.1039/C005374K
Received 18 May 2010, Accepted 22 Jun 2010
First published on the web 23 Sep 2010
This article is part of the collection: Analysis for Healthcare Diagnostics and Theranostics

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Due to their ability to serve as fluorophores and drug delivery vehicles, quantum dots are a powerful tool for theranostics-based clinical applications. In this study, microneedle devices for transdermal drug delivery were fabricated by means of two-photon polymerization of an acrylate-based polymer. We examined proliferation of cells on this polymer using neonatal human epidermal keratinocytes and human dermal fibroblasts. The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy.