Issue 40, 2011

Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

Abstract

A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors.

Graphical abstract: Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

Supplementary files

Article information

Article type
Communication
Submitted
26 Jul 2011
Accepted
01 Sep 2011
First published
19 Sep 2011

Chem. Commun., 2011,47, 11264-11266

Shedding light by cancer redox—human NAD(P)H:quinone oxidoreductase 1 activation of a cloaked fluorescent dye

W. C. Silvers, A. S. Payne and R. L. McCarley, Chem. Commun., 2011, 47, 11264 DOI: 10.1039/C1CC14578A

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