Jump to main content
Jump to site search

Issue 3, 2010
Previous Article Next Article

Ligand-assisted nickel-catalysed sp3–sp3 homocoupling of unactivated alkyl bromides and its application to the active template synthesis of rotaxanes

Author affiliations

Abstract

An efficient, mild and operationally simple Ni-catalysed sp3-carbon-to-sp3-carbon homocoupling of unactivated alkyl bromides has been developed and utilised in the active metal template synthesis of an alkyl chain axle [2]rotaxane. The key to the transformation is the use of tridentate nitrogen-donor-atom (terpy or pybox derived) ligands which inhibit competing β-hydride elimination of alkyl-Ni intermediates.

Graphical abstract: Ligand-assisted nickel-catalysed sp3–sp3 homocoupling of unactivated alkyl bromides and its application to the active template synthesis of rotaxanes

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Apr 2010, accepted on 28 May 2010 and first published on 18 Jun 2010


Article type: Edge Article
DOI: 10.1039/C0SC00279H
Citation: Chem. Sci., 2010,1, 383-386
  •   Request permissions

    Ligand-assisted nickel-catalysed sp3–sp3 homocoupling of unactivated alkyl bromides and its application to the active template synthesis of rotaxanes

    S. M. Goldup, D. A. Leigh, R. T. McBurney, P. R. McGonigal and A. Plant, Chem. Sci., 2010, 1, 383
    DOI: 10.1039/C0SC00279H

Search articles by author

Spotlight

Advertisements