Issue 4, 2010

Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C–X bond formation

Abstract

Metal catalyzed asymmetric allylic alkylation (AAA) reactions have been an extensively studied and fruitful area of research in organic chemistry. The use of heteroatom-centered nucleophiles in this reaction is a powerful method for asymmetric C–X (X = heteroatom) bond formation. This perspective summarizes developments and applications of metal catalyzed AAA reactions employing heteroatom nucleophiles.

Graphical abstract: Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C–X bond formation

Article information

Article type
Perspective
Submitted
19 Mar 2010
Accepted
01 Apr 2010
First published
18 Jun 2010

Chem. Sci., 2010,1, 427-440

Catalytic asymmetric allylic alkylation employing heteroatom nucleophiles: a powerful method for C–X bond formation

B. M. Trost, T. Zhang and J. D. Sieber, Chem. Sci., 2010, 1, 427 DOI: 10.1039/C0SC00234H

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