Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki; Hye-Sook Kim; Hiroshi Inoue; Hiroki Terauchi; Shusuke Kuge; Akira Naganuma; Yusuke Wataya; Hidetoshi Tokuyama; Masataka Ihara; Kiyosei Takasu

doi:10.1039/C0SC00125B

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites†

Daiki Morisaki,^a Hye-Sook Kim,^b Hiroshi Inoue,^a Hiroki Terauchi,^a Shusuke Kuge,^a Akira Naganuma,^a Yusuke Wataya,^b Hidetoshi Tokuyama,^a Masataka Ihara*^ac and Kiyosei Takasu*^ad

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* Corresponding authors

^a Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Japan

^b Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Japan

^c Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Japan
E-mail: m-ihara@hoshi.ac.jp

^d Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Japan
E-mail: kay-t@pharm.kyoto-u.ac.jp
Fax: +81-75-753-4610
Tel: +81-75-753-4610

Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Chemical Science

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites†

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Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

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