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Issue 20, 2010
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Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

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Abstract

Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.

Graphical abstract: Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

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Publication details

The article was received on 14 Jul 2010, accepted on 11 Aug 2010 and first published on 01 Sep 2010


Article type: Communication
DOI: 10.1039/C0OB00424C
Citation: Org. Biomol. Chem., 2010,8, 4540-4542
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    Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

    J. Pytkowicz, O. Stéphany, S. Marinkovic, S. Inagaki and T. Brigaud, Org. Biomol. Chem., 2010, 8, 4540
    DOI: 10.1039/C0OB00424C

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