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Issue 6, 2010
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Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

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Abstract

Elimination of suitable leaving groups from 3-substituted indoles under basic or acidic conditions readily provides alkylideneindolenine intermediates that may react with a large variety of nucleophilic reagents. This article highlights some recent developments of this synthetic approach for the preparation of functionalized indole derivatives.

Graphical abstract: Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

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Publication details

The article was received on 24 Sep 2009, accepted on 13 Nov 2009 and first published on 16 Dec 2009


Article type: Perspective
DOI: 10.1039/B919891A
Citation: Org. Biomol. Chem., 2010,8, 1259-1270
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    Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

    A. Palmieri, M. Petrini and R. R. Shaikh, Org. Biomol. Chem., 2010, 8, 1259
    DOI: 10.1039/B919891A

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