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Issue 9, 2010
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Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

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Abstract

Biomaterials that inactivate microbes are needed to eliminate medical device infections. We investigate here the antimicrobial nature of single-walled carbon nanotubes (SWNTs) incorporated within the biomedical polymer poly(lactic-co-glycolic acid) (PLGA). We find Escherichia coli and Staphylococcus epidermidis viability and metabolic activity to be significantly diminished in the presence of SWNTPLGA, and to correlate with SWNT length and concentration (<2% by weight). Up to 98% of bacteria die within one hour on SWNTPLGA versus 15–20% on pure PLGA. Shorter SWNTs are more toxic, possibly due to increased density of open tube ends. This study demonstrates the potential usefulness of SWNTPLGA as an antimicrobial biomaterial.

Graphical abstract: Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

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Publication details

The article was received on 17 May 2010, accepted on 13 Jun 2010 and first published on 02 Aug 2010


Article type: Paper
DOI: 10.1039/C0NR00329H
Citation: Nanoscale, 2010,2, 1789-1794
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    Antimicrobial biomaterials based on carbon nanotubes dispersed in poly(lactic-co-glycolic acid)

    S. Aslan, C. Z. Loebick, S. Kang, M. Elimelech, L. D. Pfefferle and P. R. Van Tassel, Nanoscale, 2010, 2, 1789
    DOI: 10.1039/C0NR00329H

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