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Issue 10, 2010
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Heterogeneous catalytic synthesis using microreactor technology

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The application of heterogeneous catalysis in conjunction with microreactor technology can facilitate a cleaner and scalable flow methodology for organic synthesis. In this tutorial review we present recent advances in the design of supported catalysts for emerging synthetic applications within microreactor technology. Specifically, transition metal catalysts such as palladium, copper, ruthenium, and nickel are described on silica, monolithic, magnetic nanoparticles and polymer supports. These catalysts have been utilised to promote a range of reactions including Heck, Sonogashira, Suzuki, Kumada, olefin metathesis, hydrogenation and benzannulation reactions.

Graphical abstract: Heterogeneous catalytic synthesis using microreactor technology

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Publication details

The article was received on 21 May 2010, accepted on 20 Jul 2010 and first published on 17 Sep 2010

Article type: Tutorial Review
DOI: 10.1039/C0GC00133C
Citation: Green Chem., 2010,12, 1687-1703
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    Heterogeneous catalytic synthesis using microreactor technology

    C. G. Frost and L. Mutton, Green Chem., 2010, 12, 1687
    DOI: 10.1039/C0GC00133C

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