Issue 3, 2010
From the journal:

Dalton Transactions

Fluorescence properties and cellular distribution of the investigational anticancer drugTriapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(ii) complex†

Christian R. Kowol,a   Robert Trondl,a   Vladimir B. Arion,*a   Michael A. Jakupec,a   Irene Lichtscheidlb  and  Bernhard K. Keppler*a  

* Corresponding authors

a University of Vienna, Institute of Inorganic Chemistry, Währingerstr. 42, Vienna, Austria
E-mail: vladimir.arion@univie.ac.at, bernhard.keppler@univie.ac.at
Fax: +43 1 4277 52680
Tel: +43 1 4277 52615

b University of Vienna, Institution of Cell Imaging and Ultrastructure Research, Althanstr. 14, Vienna, Austria

Abstract

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (λex = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.

Graphical abstract: Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(ii) complex

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Article information

DOI
https://doi.org/10.1039/B919119B
Article type
Communication
Submitted
14 Sep 2009
Accepted
09 Oct 2009
First published
22 Oct 2009

Dalton Trans., 2010,39, 704-706

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Fluorescence properties and cellular distribution of the investigational anticancer drug Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex

C. R. Kowol, R. Trondl, V. B. Arion, M. A. Jakupec, I. Lichtscheidl and B. K. Keppler, Dalton Trans., 2010, 39, 704 DOI: 10.1039/B919119B

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